Volume 5 Issue 4 Oct.- Dec. 2022
Original Articles
RANDOMISED SINGLE BLIND PLACEBO CONTROL STUDY ON THE EFFICACY OF CALCAREA FLUORICA 6X IN FISSURE-IN-ANO
Swarupananda Sarkar, E Siva Rami Reddy
Anal fissure is a most common anorectal disorder which affects both genders. Fissures may be acute or chronic and usually occur as a liner tear in the anoderm in the posterior midline. Adults with anal fissures usually present with pain during or after defecation, passage of bright red blood per rectum, perianal swelling, and occasional anal pruritus. Objectives: 1) To understand the various presentations of fissure-in-ano. 2) To study the changes in suffering in individuals with fissure-in-ano with administration of biochemic medicine Calcarea fluorica 6x. 3) To study the efficacy of biochemic medicine Calcarea fluorica 6x in individuals with fissure-in-ano with the comparison with placebo control. Methodology: Single blind, Prospective Interventional Placebo Control Trial Active drug ingredient: Biochemic Calcarea fluorica 6x. Placebo: Identically white colour, shape & size of sugar of milk tablets as looking like active drug. Method of Study: After diagnosis, patient would be enrolled for the study with consent sign. As per enrolment, patients would be divided into two groups (active and placebo), as per computerised randomisation. Both groups would be received identical tablets but Calcarea fluor 6x would be given to active group while identical placebo tablets would be given to placebo group. For local or external application, both groups would be advised for vaseline/ coconut oil only, as a softener. Each patient would be advised for fibrous diet, plenty of water, avoids fasting, not to postpone defecation, avoid spicy or outer food & sitz bath. Sample size: 100 (50 in Active group & 50 in Placebo group). Sampling: Computerized Randomization Sampling Conclusion: Biochemic medicine Calcarea fluorica 6x has significant efficacious role in treatment in fissure-in-ano.
